Greenberg, University of Pennsylvania, UNITED STATES PLoS Negl Trop Dis 15(3):Įditor: Robert M. Since schistosome morbidity is related to infection intensity, our results support the use of ERR as an indicator that helps avoid underestimation of praziquantel treatment efficacy and health impact.Ĭitation: Fukushige M, Chase-Topping M, Woolhouse MEJ, Mutapi F (2021) Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy. Even in the studies reporting low CR, ERR were high indicating that treatment did reduce infection intensity even though it did not completely remove the infection in some people. Our study showed the majority of studies reported high ERR (>80%) even among studies that reported low CR (<50%). Praziquantel efficacy levels increased with drug dose. ![]() We conclude that praziquantel treatment is still effective for schistosomiasis even after four decades of usage. We identified 146 scientific articles that reported efficacy levels of praziquantel treatment for schistosomiasis as determined by cure rate (CR) and/or egg reduction rate (ERR). We conducted this study to determine factors affecting drug efficacy and if the efficacy has altered in the past four decades. Reasons for the variation can be related to host attributes or parasite attributes. The drug praziquantel has been used since the 1970s to treat schistosomiasis with some variable measures of efficacy reported. Schistosomiasis is a water-borne disease caused by a group of flatworm parasites known as schistosomes. The results showed a positive effect of “PZQ treatment dose” with the current recommended dose of 40 mg/kg body weight achieving 57% to 88% CR depending on schistosome species, age of participants, and number of parasitological samples used for diagnosis, and ERR of 95%. The results showed more variability in CR, compared with ERR which was more consistent and remained high. We found that there has been no significant reduction in CR or ERR over the study period. In total, 12,127 potential articles were screened and 146 eligible articles (published from 1979 to 2020) were identified and included for the meta-analysis. Random effect meta-regression models were used to identify the factors that influence CR and/or ERR by considering differences in host characteristics and drug dose. ![]() Alongside these, EMBASE, and CAB abstracts were searched to identify relevant articles. Warez is harming producers of the software.In this systematic review and meta-analysis, a literature review was conducted using Biosis Citation Index, Data Citation Index, MEDLINE, and Web of Science Core Collection all of which were provided through Web of Science. You cannot find here any torrents or download links that would lead you to dangerous sites.įyxm.net does support free software, however we do not support warez or illegal downloads. Our experts on malware detection tested DataThief with various spyware and malware detection programs, including custom malware and spyware detection, and absolutelly no malware or spyware was found in DataThief.Īll software that you can find on our servers, including DataThief, is either freeware, shareware or open-source, some of the software packages are demo, trial or patch versions and if possible (public domain licence), we also host official full versions of software.īecause we want to be one of the fastest download sites on the web, we host all the software including DataThief on our servers. No infections have been found and downloading DataThief is completelly problem free because of that reason. Various leading antiviruses have been used to test DataThief, if it contains any viruses. It is checked for possible viruses and is proven to be 100% clean and safe. All software that you can find here is freely downloadable and legal.ĭataThief installation package is prepared to be downloaded from our fast download servers. Our collection also doesn't contain any keygens, because keygen programs are being used in illegal ways which we do not support. There is no crack, serial number, hack or activation key for DataThief present here. Every software that you are able to download on our site is legal. You cannot download any crack or serial number for DataThief on this page. Typically, you scan a graph from a publication, load it into DataThief, and save the resulting coordinates, so you can use them in calculations or graphs that include your own data DataThief III is a program to reverse engineer data points from a graph.
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